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April 10, 2021
bio生物学essay代写 It has the capabilities to produce the “patient-specific anatomical models” for full-size adult by using the tunable alginate bioinks.
Article Summary bio生物学essay代写
In the article, FRESH 3D Bioprinting a Full-Size Model of the Human Heart Mirdamadi et al. (2020) examined the FRESH 3D model of a human heart in full size. The 3D bioprinting recent advances has enabled the expansion of the designed space for producing a geometrically complex tissues using hydrogels with the mechanical properties. FRESH (Freeform Reversible Embedding of Suspended Hydrogels) approach allows us to integrate soft biomaterials in a thermoreversible support ranging from few millimeters to centimeters. This study expands the printable size of the human heart into a full size model through a FRESH bioprinting. This is done using the patient derived MRI (magnetic resonance imaging) (Mirdamadi, Tashman, Shiwarski, Palchesko, & Feinberg, 2020, p. 6453). bio生物学essay代写
The3D printing is a standard approach which converts the clinical imaging data patient specific anatomical model. This process of 3D consists of image acquisition, segmentation, digital model creation and 3D printing. Though, 3D printing techniques can give us full size adult organ model it cannot imitate the mechanical properties of the native tissues. Thereby, this study report the advancement of FRESH approach with the ability to give full size adult human heart model using a hydrogel material that imitates the native organs (p. 6453).
For the FRESH printing three alginate concentrations were made (2, 4 & 6% w/v).
The Support Bath and Alginate preparation are very significant for the FRESH 3D Bio-printing. For the Alginate preparation, FMC Biopolymer (all alginates) was solubilized the sufficient alginate powder’s amount in deionized (DI) water. Support Bath prepared by using FRESH v2.0 support bath protocol that involves intricate coacervation to produce the micro-particles of gelatin.
For the preparation of the FRESH support bath for the adult human heart, 20 L of the forerunner gelatin outcome was coacervated overnight. Once the process is completed the micro-particles were washed two times and resuspending them in DI water as well as centrifuged for 2 minutes at 750g. To make the compacted gelatin Support Bath material the twice washed micro-particles were again resuspended third time in 0.1% (w/v) CaCl2 solution as well as centrifuged for 5 minutes at 2000g (p. 6454). bio生物学essay代写
FRESH bio-printing has demonstrated in this article. It has the capabilities to produce the “patient-specific anatomical models” for full-size adult by using the tunable alginate bioinks. Specifically, models impressionist Cardiac tissue’s mechanical properties and subsequently durable to suture, handle, and perfuse to make them perfect candidates for usage as surgical training tools. In the current state, the full adult size cardiac scaffold signifies a vital step toward organ size cardiac tissues, fabricating realistic feeling as well as lays the basis toward the full adult size organs printing for cardiac regenerative and tissue engineering medicine. It could be a significant tool for planning purposes and surgical modeling (p. 6458).
Reference: bio生物学essay代写
Mirdamadi, E., Tashman, J., Shiwarski, D., Palchesko, R., & Feinberg, A. (2020). FRESH 3D Bioprinting a Full-Size Model of the Human Heart. ACS Biomaterials Science & Engineering , 6453-6459.
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